E3 Ligase Ligand 2

Research use only, not for human use.

An E3 ligase ligand for PROTAC.

An E3 ligase ligand for PROTAC.

Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. Thalidomide-OH is a putative hydroxylated thalidomide metabolite. Thalidomide-OH has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells.

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PROTACs

E3 Ligase Ligand

E3 Ligase Ligand

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5054-59-1

274.232

C13H10N2O5

>98% (HPLC)

In Vitro:?DMSO : ≥ 36.5 mg/mL (133.10 m)

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O

2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione

(-20℃)

With Ice Pack

≥ 2 years