Cart
sales@molnova.com
E3 Ligase Ligand 2
CAS No. 5054-59-1
E3 Ligase Ligand 2( —— )
Catalog No. M14725 CAS No. 5054-59-1
An E3 ligase ligand for PROTAC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 26 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameE3 Ligase Ligand 2
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn E3 ligase ligand for PROTAC.
-
DescriptionAn E3 ligase ligand for PROTAC.
-
In VitroThalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. Thalidomide-OH is a putative hydroxylated thalidomide metabolite. Thalidomide-OH has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells.
-
In Vivo——
-
Synonyms——
-
PathwayPROTACs
-
TargetE3 Ligase Ligand
-
RecptorE3 Ligase Ligand
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number5054-59-1
-
Formula Weight274.232
-
Molecular FormulaC13H10N2O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 36.5 mg/mL (133.10 m)
-
SMILESC1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O
-
Chemical Name2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Robb CM, et al. Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580.
molnova catalog
related products
-
E3 Ligand-Linker Con...
An E3 ligase ligand-linker conjugate for PROTAC.
-
PROTAC-VHL-ligand
PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.
-
VH 298
A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.
